Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC007
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-15 10:18
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 3x1/4 caps Madopar HBS 1 uvece New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 22, 'TN': 17, 'TP': 20, 'FP': 13}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 41, 'TN': 29, 'TP': 1, 'FP': 1}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 12, 'TN': 8, 'TP': 30, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 12, 'TP': 22, 'FP': 18}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 11.696
timePerCircleCoV 0.186208
timePerCircleSlope 0.0206027
meanError 1.65512
tremorFreq 5.66406
tremorRelPower 43.6001
tremorGyroAmpMean 0.0357711
tremorGyroAmpSlope 0.00132446
tremorGyroAmpCoV 0.603033
tremorCoordAmpMean 0.132421
tremorCoordAmpSlope -0.0118539
tremorCoordAmpCoV 2.58321
tremorAccAmpMean 0.0941019
tremorAccAmpSlope 0.00070301
tremorAccAmpCoV 0.150427
tremorPcRelVar 0.776204
tremorPcX 0.488208
tremorPcY -0.872727

Circle Segment 1

Duration 11.96 s, Accuracy Estimate 1.258 (lower is better)

Circle Segment 2

Duration 12.16 s, Accuracy Estimate 1.17 (lower is better)

Circle Segment 3

Duration 9.08 s, Accuracy Estimate 2.36 (lower is better)

Circle Segment 4

Duration 9.88 s, Accuracy Estimate 2.926 (lower is better)

Circle Segment 5

Duration 12.48 s, Accuracy Estimate 1.043 (lower is better)

Circle Segment 6

Duration 12.08 s, Accuracy Estimate 1.312 (lower is better)

Circle Segment 7

Duration 12.8 s, Accuracy Estimate 1.693 (lower is better)

Circle Segment 8

Duration 9.64 s, Accuracy Estimate 1.121 (lower is better)

Circle Segment 9

Duration 10.28 s, Accuracy Estimate 1.361 (lower is better)

Circle Segment 10

Duration 16.6 s, Accuracy Estimate 2.308 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 29.32
timePerSpiralCoV 0.126712
timePerSpiralSlope -0.0176113
meanError 1.55882
tremorFreq 5.37109
tremorRelPower 64.0828
tremorGyroAmpMean 0.0784829
tremorGyroAmpSlope 0.00511178
tremorGyroAmpCoV 0.448944
tremorCoordAmpMean 0.0680094
tremorCoordAmpSlope 0.00124877
tremorCoordAmpCoV 0.340703
tremorAccAmpMean 0.0607872
tremorAccAmpSlope 0.00172571
tremorAccAmpCoV 0.350886
tremorPcRelVar 0.6974
tremorPcX 0.863817
tremorPcY -0.503805

Spiral Segment 1

Duration 37.04 s, Accuracy Estimate 1.479 (lower is better)

Spiral Segment 2

Duration 32.6 s, Accuracy Estimate 1.47 (lower is better)

Spiral Segment 3

Duration 27.4 s, Accuracy Estimate 1.562 (lower is better)

Spiral Segment 4

Duration 27.24 s, Accuracy Estimate 1.469 (lower is better)

Spiral Segment 5

Duration 24.28 s, Accuracy Estimate 1.591 (lower is better)

Spiral Segment 6

Duration 28.08 s, Accuracy Estimate 1.796 (lower is better)

Spiral Segment 7

Duration 30.8 s, Accuracy Estimate 1.639 (lower is better)

Spiral Segment 8

Duration 30.52 s, Accuracy Estimate 1.493 (lower is better)

Spiral Segment 9

Duration 25.44 s, Accuracy Estimate 1.434 (lower is better)

Spiral Segment 10

Duration 29.8 s, Accuracy Estimate 1.655 (lower is better)

Elel

eDurationMean 0.485417
eDurationStd 0.100494
eDurationStdnorm 0.207027
eDurationMedian 0.465
eDurationQuartdelta 0.1125
eDurationQuartdeltanorm 0.241935
eDurationKurt 4.93369
eDurationTrenddiff -0.075
eDurationTrendratio 0.852217
eWidthMean 6.86075
eWidthStd 2.57676
eWidthStdnorm 0.375579
eWidthMedian 6.786
eWidthQuartdelta 2.9835
eWidthQuartdeltanorm 0.439655
eWidthKurt 2.79865
eWidthTrenddiff 1.521
eWidthTrendratio 1.26531
eHeightMean 17.9627
eHeightStd 2.29519
eHeightStdnorm 0.127775
eHeightMedian 17.8425
eHeightQuartdelta 2.808
eHeightQuartdeltanorm 0.157377
eHeightKurt 3.7429
eHeightTrenddiff 0.8775
eHeightTrendratio 1.05051
eAspectMean 0.382048
eAspectStd 0.134607
eAspectStdnorm 0.352329
eAspectMedian 0.377976
eAspectQuartdelta 0.210285
eAspectQuartdeltanorm 0.556344
eAspectKurt 2.25558
eAspectTrenddiff 0.0944655
eAspectTrendratio 1.30006
eSlantMean 0.0757806
eSlantStd 0.195863
eSlantStdnorm 2.58461
eSlantMedian 0.0590783
eSlantQuartdelta 0.317658
eSlantQuartdeltanorm 5.3769
eSlantKurt 2.34862
eSlantTrenddiff 0.177589
eRtopMean 0.798073
eRtopStd 0.15713
eRtopStdnorm 0.196886
eRtopMedian 0.858804
eRtopQuartdelta 0.143988
eRtopQuartdeltanorm 0.167661
eRtopKurt 4.04035
eRtopTrenddiff 0.0495194
eRbotMean 0.773915
eRbotStd 0.521503
eRbotStdnorm 0.673851
eRbotMedian 0.615576
eRbotQuartdelta 0.56329
eRbotQuartdeltanorm 0.915061
eRbotKurt 4.97446
eRbotTrenddiff -0.313999
eRrightMean 0.888993
eRrightStd 0.0730268
eRrightStdnorm 0.0821456
eRrightMedian 0.909
eRrightQuartdelta 0.0816062
eRrightQuartdeltanorm 0.0897759
eRrightKurt 3.95035
eRrightTrenddiff 0.0503897
eRleftMean 0.342134
eRleftStd 0.161283
eRleftStdnorm 0.471403
eRleftMedian 0.317119
eRleftQuartdelta 0.213767
eRleftQuartdeltanorm 0.67409
eRleftKurt 3.51472
eRleftTrenddiff -0.184423
lDurationMean 0.603919
lDurationStd 0.112935
lDurationStdnorm 0.187004
lDurationMedian 0.58
lDurationQuartdelta 0.13125
lDurationQuartdeltanorm 0.226293
lDurationKurt 5.54133
lDurationTrenddiff -0.1325
lDurationTrendratio 0.802974
lWidthMean 11.251
lWidthStd 4.82982
lWidthStdnorm 0.429281
lWidthMedian 11.817
lWidthQuartdelta 6.52275
lWidthQuartdeltanorm 0.55198
lWidthKurt 2.31894
lWidthTrenddiff 5.4405
lWidthTrendratio 1.65957
lHeightMean 41.1113
lHeightStd 3.47782
lHeightStdnorm 0.0845954
lHeightMedian 40.95
lHeightQuartdelta 4.563
lHeightQuartdeltanorm 0.111429
lHeightKurt 2.29541
lHeightTrenddiff 0.2925
lHeightTrendratio 1.00717
lAspectMean 0.272356
lAspectStd 0.113749
lAspectStdnorm 0.417649
lAspectMedian 0.273684
lAspectQuartdelta 0.167596
lAspectQuartdeltanorm 0.61237
lAspectKurt 2.08332
lAspectTrenddiff 0.14412
lAspectTrendratio 1.74211
lSlantMean 0.118121
lSlantStd 0.128928
lSlantStdnorm 1.09148
lSlantMedian 0.135952
lSlantQuartdelta 0.202953
lSlantQuartdeltanorm 1.49284
lSlantKurt 2.07944
lSlantTrenddiff 0.196102
lRtopMean 0.828483
lRtopStd 0.118547
lRtopStdnorm 0.143089
lRtopMedian 0.846154
lRtopQuartdelta 0.122732
lRtopQuartdeltanorm 0.145047
lRtopKurt 3.52784
lRtopTrenddiff 0.0649385
lRbotMean 0.55195
lRbotStd 0.382502
lRbotStdnorm 0.693001
lRbotMedian 0.409836
lRbotQuartdelta 0.399737
lRbotQuartdeltanorm 0.975359
lRbotKurt 4.22122
lRbotTrenddiff -0.350009
lRrightMean 0.908392
lRrightStd 0.0515332
lRrightStdnorm 0.0567301
lRrightMedian 0.919075
lRrightQuartdelta 0.0697972
lRrightQuartdeltanorm 0.0759428
lRrightKurt 2.58121
lRrightTrenddiff 0.0419382
lRleftMean 0.238168
lRleftStd 0.120674
lRleftStdnorm 0.506678
lRleftMedian 0.191375
lRleftQuartdelta 0.174772
lRleftQuartdeltanorm 0.913244
lRleftKurt 5.85676
lRleftTrenddiff -0.104343

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.95654
sumTouchScores 14.3481
meanMovementTime 0.535
numTouches 15
undershootPercentage 0
overshootPercentage 13.3333

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.6927
sumTouchScores 15.2394
meanMovementTime 0.870952
numTouches 22
undershootPercentage 9.09091
overshootPercentage 18.1818

ZigZag

numZigzags 5
timePerZigzagMean 13.776
timePerZigzagCoV 0.0714958
timePerZigzagSlope -0.0345528
meanError 3.07914
tremorFreq 6.05469
tremorRelPower 53.1711
tremorGyroAmpMean 0.091597
tremorGyroAmpSlope 0.00170397
tremorGyroAmpCoV 0.365491
tremorCoordAmpMean 0.201335
tremorCoordAmpSlope 0.00284349
tremorCoordAmpCoV 0.882962
tremorAccAmpMean 0.129169
tremorAccAmpSlope 0.00042764
tremorAccAmpCoV 0.317239
tremorPcRelVar 0.789744
tremorPcX -0.153745
tremorPcY -0.988111

ZigZag Segment 1

Duration 14.0 s, Accuracy Estimate 3.726 (lower is better)

ZigZag Segment 2

Duration 14.88 s, Accuracy Estimate 2.859 (lower is better)

ZigZag Segment 3

Duration 14.48 s, Accuracy Estimate 3.611 (lower is better)

ZigZag Segment 4

Duration 12.92 s, Accuracy Estimate 2.621 (lower is better)

ZigZag Segment 5

Duration 12.6 s, Accuracy Estimate 2.579 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 10.84
timePerZigzagCoV 0.197805
timePerZigzagSlope -0.104059
zigzagHeightMean 83.0688
zigzagHeightCoV 0.0420348
zigzagHeightSlope 0.0218381
meanError 0.0389832
tremorFreq 5.95703
tremorRelPower 40.0941
tremorGyroAmpMean 0.068248
tremorGyroAmpSlope 0.00923148
tremorGyroAmpCoV 0.30048
tremorCoordAmpMean 0.158086
tremorCoordAmpSlope 0.0148986
tremorCoordAmpCoV 0.242667
tremorAccAmpMean 0.11416
tremorAccAmpSlope 0.01476
tremorAccAmpCoV 0.284493
tremorPcRelVar 0.577964
tremorPcX 0.244793
tremorPcY 0.969575

ZigZag Offset Segment 1

Duration 14.6 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 2

Duration 10.52 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 3

Duration 10.0 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 4

Duration 9.72 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 5

Duration 9.36 s, Accuracy Estimate 0.061 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.76}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.2926301539465723}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8613633895975652}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}